It is one of the few primitive emotions that drive mankind to action. Often times what is most feared is what is not understood. If you cannot understand something, if you cannot know or comprehend the dynamics of a thing, then it drives you to fear. What does mankind do when afraid of something it doesn't understand? It lashes out for its own inadequacies at the thing it does not understand. Sometimes, mankind gets lucky, and it can over power that which it does not understand. Sometimes, that which it does not understand, fights back.
Something began to appear that mankind did not understand. Taking the form of those among them. Mutants, freaks, with natural abilities beyond those of mankind. Some were physical, some were mental, some were obvious, some were subtle, but never the less, all of them were feared.