Higashi no Eden is by far the best anime series this season out of the ones I've seen. I like how the main character even namedrops Jason Bourne's name in the 1st episode. The female cop letting him off the hook due to difference in "size" was hilarious. The attention to detail having the setting situated in DC was phenomenal. Also the voice acting for English speaking characters was spot-on... unlike Back.
Honey & Clover was one of the best anime series ever made and with the same animation team, a more action filled plot with espionage, AND the brilliant move to have School Food Punishment provide music for the ED... this series is a slam dunk win.

My only gripe is that the characters look so close to ones from Honey & Clover that you forget you're watching a spy/terrorist anime and not a slice-of-life romantic comedy.
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I watched the first 10 minutes of Shangri-la and had to stop because it was so bad. So many outlandish yet stereotypical characters. The transvestite engineer in Gurren Laggan was hilarious and awesome... the transvestite characters in Shangri-la make me want to punch my monitor. Seriously, what is the deal with the pudgy overly effeminate boy wearing white-face? Who the FOLK thought this would make an endearing character. The only reason I would watch this anime is to see if this character gets a stray boomerang to the face.
I sooooo should have listened to Ravik's "fishiness" detector.
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K-ON! is not bad. You can never go wrong with KyoAni b/c at least the animation will be state of the art. Again the attention to detail is excellent in this anime. I love how they try to be as accurate as possible when they have their characters play instruments.
The 2nd episode was more engaging than the first. You get to see the girls enter a guitar store where Yui falls in love with a $2500 Les Paul.
I would like it if the humor had more bite/sarcasm (i.e. something along the lines of Lucky Star). Unfortunately, this anime is geared towards younger kids and they don't include much in terms of inside jokes that only adults would get. The DMC spoof was hilarious though.
I'll continue to watch this as it spurs me to think what Ecchan and her crew must have gone through as a 6-member Chatmonchy in high school @ Tokushima.
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Modnar said that FMA: Brotherhood was a continuation of the original BONES anime but that is soooo not the case. The fact there were so many characters that were alive who are supposed to be dead clued me in on that fact right away.
Basically they're telling the same story AGAIN all the way from the beginning but they will stay much closer to the manga this time around.
HOWEVER, the 1st series took 51 episodes, Brotherhood will only be 13 episodes long.

I'm skeptical as to what this series will achieve. It's the same animation group, half the storyline will be the same...
I think the main reason why they did this is b/c the manga is still ongoing and this way they'll able to continue the story with subsequent series. (The way they diverged from the manga in the original series there's no way they could continue it based on the manga)